Our group is interested in the regulation of lymphocyte activity and function during infections, cancer and autoimmunity. Current research efforts are focused on the activating T cell receptor (TCR) and inhibitory PD1 pathways in T cells. We apply multidisciplinary approaches that combine cutting-edge fluorescence microscopy with biophysics, biochemistry and molecular biology to elucidate how conformations, modifications, localizations and assembly of signaling molecules control signal transduction and thereby T cell activity. Newly identified molecular mechanisms are characterized and targeted in vivo, specifically in mice, to modulate anti-tumor responses and autoimmunity. Our goal is to determine the potential of these novel mechanisms as future drug targets for immunotherapies.
We are recruiting! A fully funded EURIDoc PhD position is available in the lab to investigate how to modulate T cell signaling for improved anti-tumor responses in vivo, or how to analyze T cell signaling mechanisms using single molecule microscopy. Information for the interested applicants can be found here.
Full time position for Laboratory Manager/Research Assistant is available in the lab. More information can be found here.
Contact us by email (email@example.com) if you are interested in working in our lab for your Bachelor’s or Master’s thesis.
Prof. Dr. Björn Lillemeier
Biology 3 / CIBSS Excellence Cluster
Email (office): firstname.lastname@example.org